Enhanced Creatinine and Estimated Glomerular Filtration Rate Reporting to Facilitate Detection of Acute Kidney Injury

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Enhanced creatinine and estimated glomerular filtration rate reporting to facilitate detection of acute kidney injury.

OBJECTIVES While acute kidney injury (AKI) can be diagnosed based on specified increases in a patient's plasma creatinine level, standard creatinine reporting methods typically only flag creatinine results as abnormal when outside the reference range and often fail to identify rising creatinine values indicative of AKI. Here, we evaluate the impact of this limitation in standard creatinine repo...

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Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate?

Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Although several groups are working on developing and validating biomarkers of kidney injury and the glomerular filtration rate (GFR), the proposed diagnostic criteria from the Acute Kidney Injury Network are based on an absolute increase in serum creatinine ≥0.3 mg/dl (≥26.4 μmol/l), a percenta...

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Estimated Glomerular Filtration Rate Correlates Poorly with Four-Hour Creatinine Clearance in Critically Ill Patients with Acute Kidney Injury

Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is needed, and some published data suggest that equations based on serum creatinine that estimate glomerular filtration rate (eGFR) can provide t...

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Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injury.

Acute kidney injury (AKI) is increasingly common and a significant contributor to excess death in hospitalized patients. CKD is an established risk factor for AKI; however, the independent graded association of urine albumin excretion with AKI is unknown. We analyzed a prospective cohort of 11,200 participants in the Atherosclerosis Risk in Communities (ARIC) study for the association between b...

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Automatic Reporting of Creatinine-based Estimated Glomerular Filtration Rate in Children: Is This Feasible?

Creatinine, although widely used as a biomarker to measure renal function, has long been known as an insensitive marker of renal impairment. Patients with reduced renal function can have a creatinine level within the normal range, with a rapid rise when renal function is significantly reduced. As of 1976, the correlation between height, the reciprocal of creatinine, and measured glomerular filt...

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ژورنال

عنوان ژورنال: American Journal of Clinical Pathology

سال: 2015

ISSN: 1943-7722,0002-9173

DOI: 10.1309/ajcp05xbcqphtlgq